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	Provedor de dados BJMBR (1) Autor Bhushan,A. (1) Hacker,M.P. (1) Tritton,T.R. (1) Palavra-chave Cisplatin (1) Leukemia (1) Methotrexate transport (1) Phosphorylation (1) Resistance (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 1999 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Collateral methotrexate resistance in cisplatin-selected murine leukemia cells BJMBR Bhushan,A.; Hacker,M.P.; Tritton,T.R.. Resistance to anticancer drugs is a major cause of failure of many therapeutic protocols. A variety of mechanisms have been proposed to explain this phenomenon. The exact mechanism depends upon the drug of interest as well as the tumor type treated. While studying a cell line selected for its resistance to cisplatin we noted that the cells expressed a >25,000-fold collateral resistance to methotrexate. Given the magnitude of this resistance we elected to investigate this intriguing collateral resistance. From a series of investigations we have identified an alteration in a membrane protein of the resistant cell as compared to the sensitive cells that could be the primary mechanism of resistance. Our studies reviewed here indicate decreased tyrosine... Tipo: Info:eu-repo/semantics/article Palavras-chave: Methotrexate transport; Resistance; Cisplatin; Leukemia; Phosphorylation. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700005 Registros recuperados: 1 Primeira ... 1 ... Última

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